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Negative Pressure Wound Therapy

Evidence & references by indication

Negative pressure wound therapy applies controlled sub-atmospheric pressure to a wound to reduce oedema, promote granulation and, with instillation, assist wound cleansing. The references below are the peer-reviewed evidence base underpinning its use, organised by clinical indication. Each entry links to the article via its DOI and, where available, PubMed.

A clinical reference list for healthcare professionals. It summarises published evidence and does not replace individual clinical judgement. Guideline positions from the Wound Healing Association of Southern Africa (WHASA) and international bodies (EWMA) are included where relevant.

463 sources, 444 formally appraised, across 13 indications, each with an integrity verdict.

463 sources
13 indications
444 formally appraised (CAT / AGREE II)
441 figures checked
122 RCTs · 139 meta-analyses/SRs
1997–2026

Indications — the RSA clinical position

Cross-cutting categories — not indications

These are browsing categories, not clinical indications. Nothing filed here is a therapy a medical scheme would be asked to fund in its own right.

Appraised study grid

Each card carries two different judgements. The appraisal badge is a formal critical appraisal of the source — GRADE certainty for a study, or an AGREE II rating out of 7 for a guideline or consensus document. The figures badge is a mechanical check of whether the numbers quoted on this site were found in the source PDF; it says nothing about the quality of the study. A paper can have its figures checked and still be appraised GRADE Very low.